From I-80/94:

Take the Calumet Avenue exit South to 45th Street west (after the railroad tracks). Turn right (west) and go to 421 on the right side of the street, next to the TIMES building.

From the South:

Take Indianapolis Blvd. (Rte. 41) north to 45th Street. Turn Left (west). At Calumet Avenue 45th street comes to a break. Turn left (south) onto Calumet Avenue and travel over the railroad tracks. Where 45th Street picks up again, turn right (west) and go to 421 on the right side of the street, next to the TIMES building.